Quantum carbon dot-gold nanoparticle hybrid nanomaterials as new generation contrast agents in bioimaging

"daha sonra doldurulacCarbon dot-gold nanoparticle hybrid systems [CD/AuNP) show great potential for biological imaging of cancer due to the enhanced photoluminescence capability arising from the synergistic coupling between the carbon dots and the gold nanoparticles called fluorescence resonance energy transfer (FRET). Compared to conventional dyes, CD/AuNP hybrid systems do not exhibit bleaching effects, so their fluorescence capacity does not decrease over time. Also, this hybrid system does not exhibit cellular cytotoxicity. Traditionally, CD/AuNP hybrids are prepared separately by wet chemical methods and then mixed together. Namely, both nanoparticle solutions (CD and AuNP) are prepared in different reaction containers and then mixed together to obtain the hybrid. However, in the proposed solid-state synthesis method, it is possible to prepare the hybrid in the same reaction container, which shortens the time and increases the photoluminescence yield of the nanoparticles. The aim of this study is to investigate the photoluminescence properties of CD/AuNP hybrid systems obtained with different reaction parameters via a one-pot solid-state synthesis method. The photoluminescent properties of the synthesized particles were investigated by using fluorescent spectroscopy. The particles were used as cellular imaging agents on different cancer cell lines such as A549, Panc02, and MCF -7. HDF was used as a control. Afterward, the cellular proliferation capacity, cellular cytotoxicity, and bio-imaging properties of the CD /AuNP systems were analyzed to find the most effective system for further studies.aktır"