The synthesis, characterisation and the investigation of biological activity of the novel complexes of 4-benzoyl-1,5-diphenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide with some transition metals

Aromatic sulfonamides are well known as inhibitors of the carbonic anhydrase enzyme.The metal complexes of sulfonamides are also potent inhibitors of the carbonic anhydrase. Carbonic anhydrase inhibitors, which reduce aqueous production with a corresponding decrease in intraocular pressure (IOP), have been used as ocular hypotensive agents for the treatment of glaucoma. In this study the syntheses of Co(II), Ni(II), Cu(II), Zn(II) complexes of the 4-Benzoyl-1,5-diphenyl-./V-(5 -sulfamoyl-1,3,4-thiadiazol-2-yl)-1 /f-pyrazole-3 -carboxamide were aimed. The structures of synthesized compounds were elucidated by using IR, 'H-NMR and 13C-NMR spectroscopies, X-ray diffraction method and elementel analysis. The inhibitory effect of synthesized compounds were experimented on human erythrocyte carbonic anhydrase (CA-I ve CA-II) by using pH-stat and UV spectroscopy methods. Keywords: Carbonic Anhydrase, glaucoma, inhibition, metal complexes, pyrazole carboxilic acid derivatives.