Aortik valf sklerozu olan hastalarda peroksinitrit ve iz elementleri

Aortic valve sclerosis (AVSc), is thickening and calcification of the aortic valve leaflets. The objective of this study was to investigate the relationship between AVSc and serum of peroxinitrite, zinc, selenium, copper, and iron. The study included 40 AVSc patients (75% females and 25% males) and were compared to same gender ratio of healthy control groups. The diagnosis of AVSc underwent based on comprehensive echocardiographic. Blood samples were taken for the determination peroxynitrite level by spectrophotometric method. Zinc and copper concentrations were determined by use of an atomic absorption spectroscopy. Selenium by utilize of inductively coupled plasma mass spectrometry device and iron by use of Beckman Coulter instrument were measured. There were significant differences in body mass index, blood pressure, and diabetes between the patient and the healthy subjects (p<0.05). The mean serum of peroxinitrite concentrations were significantly higher in AVSc subjects (6.05±1.83 µmol/L) than that of the control levels (2.61±0.97 µmol/L) (p=0.000). Differences in serum Fe, Se, and Cu levels were found between the patients and the healthy donors (p>0.05). A significant decrease was found in the serum zinc of patients group when the compared with the control group (p<0.01). Serum peroxinitrite concentrations could be markedly in patient with AVSc. Likewise, they had imbalance in some of the trace elements in their blood. An elevation in serum copper levels and a decreases of serum Se, Zn, and Fe concentrations in the valves subjectss as compared with the normal valves. The AVSc patients had higher prevalence of diabetes, hypertension, and obesity. Keywords: Aortic valve sclerosis, Peroxynitrite, Selenium, Zinc, Copper, Iron