Investigation of voltammetric behavi̇our of some antibiotics and determinati̇on of their quantification conditions

Antibiotics, in general term, are drugs used for the treatment of infections caused by microorganisms. Antibiotics are placed on top of the prescribed drug list for patients consulting a doctor. Methods of high accuracy and precision are developed for the residue analysis of antibiotics, which are used fort he treatment and protection of living things, and their metabolites in various tissues and biological fluids along with some nutrients such as milk and honey,. The most advanced techniques developed fort his purpose are chromatographic techniques. In this work, electrochemical behavior of 6 different antibiotics (cefazolin, cefuroxime, ceftriaxsone, penicillin G, ampicillin ve gentamicin) from three particular class (betalactam antibiotics, penicillins and aminoglycosides) were investigated by cyclic voltammetry using graphite pencil electrode in Britten-Robinson buffer solutions (pH 2, 5 and 9) afterwards, oxidation peaks of antibiotics were determined using differential pulse voltammetry and calibration graphics for each antibiotic were plotted using peak current intensities determined by using calibration standard solutions. Linear working range and quantitation sensitivity of antibiotics were discussed regarding the correlation coefficients and line equations drawn according to the method of least squares Keywords: Antibiotic, voltammetry, pencil graphite electrode