The effects of lithium borate on antioxidant profile and some biochemical parameters in cadmium induced rats

This study planed to determine protective effect of lithium borate in cadmium induced rats. In the study, 20 Wistar-Albino male rats were used. Rats were divided in to four groups each of which includes 5 rats. Group I; control group (standart pellet food + water +serum physiological), Group II; cadmium (0,025 mmol/kg/ip/one dose), Group III; lithiumborate (15 mg/kg/day oral, for 5 days) Group IV; cadmium+ lithiumborate (0,025 mmol/kg/ip/one dose + 15 mg/kg/day orally). At the end of the study MDA, GSH, SOD CAT, Fe, Ca, Mg and K levels were investigated in blood samples. According to the obtain results MDA levels of lithiumborate induced group were decreased significantly when compared with control group (p<0.05). Besides, when the SOD levels showed statistically important increasing in lithiumborate induced group (p<0.05), GSH levels were decreased at statistically important at (p<0.05) degree. CAT levels decreased but these decreasing was not statistically important in lithiumborate induced group. Furthermore, statistically important decreases were dedected on Fe and Ca levels in Cd induced group (p<0.05). As a result, lithiumborate supported oxidant/antioxidant balance by enhance SOD levels and prevent MDA generation.