Evaluation of thyroid hormone parameters and dyslipidemia in type 2 diabetic patients

Thyroid diseases and diabetes are the most common endocrine disorders in clinical practice and have been shown to frequently affect each other. The frequency of thyroid dysfunction is higher in the diabetic population. There are many effects of thyroid hormones in the regulation of lipid metabolism. In this study, the aim was to assess the relationship between Thyroid hormones and lipid parameters in type II diabetic patients. The thyroid parameters measured in our study were obtained using a Beckman Coulter Unicel DxI800, USA instrument; FBG, ALT, and lipid profiles were studied with Beckman Coulter AU5800, US device and HbA1c Biorad Variant 2, USA. Having compared between type II diabetic patients and control groups, it was found a significant increase in FBG, HbA1C, ALT, T-Cholesterol, HDL-C, LDL-C, CRP, TSH parameters , (p<0.05), in the type II diabetic patients, whereas no significant difference regarding FT4 and HGB parameters were found. It has been found in T2DM group a significant relationship between TSH and TG (p<0.05), besides it has been found a significant relationship among FT3 , T-Cholesterol and HDL-C. Also, it has been found a significant relationship between FT4 and LDL-C (p<0.05) in Anti-TPO (Negative) group . It didn't show a significant relationship between Thyroids parameters and lipid profiles (p>0.05) in Anti-TPO (Positive) group .This finding is accordant with other studies showing that type 2 diabetes increases thyroid disease and dyslipidemia risk. Findings from this study show that there may be a relationship between dyslipidemia and thyroid parameters, but advanced molecular tests are needed to confirm it. In addition, we can foresee that thyroid hormone parameters and lipid profile can be used for in follow-up of Type 2 diabetes patients.