Kompakt bir sol ventriküler destek cihazının geliştirilmesi: İstanbul Kalp versiyon II

The shortage of heart donors has led to the development of mechanical circulatory support devices for patients suffering from heart failure. Most of these devices are bulky and require adequate space in the chest cavity for implantation, mainly left ventricular assist devices. However, patients with small chest cavities face challenges during implantation. Therefore, it is crucial to develop a compact version of the left ventricular assist device that is smaller yet capable of providing sufficient flow rate, head pressure, and biocompatibility. In this research study, a novel compact left ventricular assist device is designed and developed for patients with small chest cavities. Firstly, the significance of the research is presented, including the statistical information regarding heart-failing patients and the number of available donors worldwide. Subsequently, the main aim behind this research is elaborated. Then, a brief literature review of the human cardiovascular system is reported, and the reasons that led to heart failure are discussed. Following this, mechanical circulatory support devices are presented, which are used to support the failing heart. Then, a rationale for the various kinds of these devices is provided, followed by a discussion of the evolution of the blood pump generations. In the third part of this thesis, the design and development of the ventricular device is outlined, which elaborates the design process. A prototype model of the blood pump was manufactured based on the simulation results. These prototyped models of the blood pumps are then extensively tested in vivo and in vitro to verify hydraulic and hemolytic efficiency. The results of both device evaluations are on par with those of commercially available devices. In the future, acute tests can provide an in-depth analysis of the developed prototype of short-term assessment. Later, a mock circulatory loop was designed and developed to test the working performance of the developed prototype device in vitro scenario.