NRG1 genindeki iki SNP'li bir haplotip ile şizofreni hastalığının genetik ilintisinin incelenmesi

The earliest gene reported to be linked with schizophrenia is NRG1 which has a number of susceptibility alleles at many SNP (single nucleotide polymorphism) loci. In this study, the genetic association of schizophrenia with two SNPs located in the NRG1 gene -rs4560751 and rs3802160- has been investigated. The study has been planned in case-control format. The case group was consisted of 96 schizophrenia patients and the control group was 100 healthy controls living in Malatya-Turkiye. Two SNPs mentioned above have been genotyped in these groups and the distributions of their alleles and genotypes were compared between two groups. The statistical significances of differences were tested with Pearson's Chi-Squared method. The statistical tests showed there were no significant difference between the case and control groups for the distributions of the alleles or genotypes of two NRG1 SNPs. As conclusion, our study revealed that the SNPs rs4560751 and rs3802160 in the NRG1 gene were not associated to schizophrenia in our sample.