Rap-stoermer reaction: Optimization of the synthesis of some substituted benzofurans

The reaction of substituted salicylaldehydes with α-chlorketones to obtain benzofuran-2-yl (alkyl/aryl) ketones, which is a dickman type aldol condensation product in base, solvent and temperature environment, is called the Rap-Stoermer reaction. In this study, Benzofuran-2-yl (Alkyl / aryl) ketones were synthesized by heating substituted salicylaldehydes and α-chlorketones in a base and solvent-free seal (closed cup) environment. Reaction conditions were optimized in terms of yield, time, cost and environment. Characterization of the synthesized compounds was done using spectroscopic methods such as FT-IR, 1H-NMR, 13C-NMR and LC-MS. Key Words: Benzofuran, Solvent Free; One-pot Synthesis; Rap-Stoermer Reaction