The effects of resveratrol on cell proliferation by angiotensin ii in high glucose media in rat aortic primer vascular smooth muscle cell culture

Diabetes mellitus is an endocrine metabolic disease which is associated with cardiovascular diseases and is related to the deficiency of pancreatic insulin secretion or its effects. Hyperglycemic-induced high cell proliferation has an important role in the pathgenesis of Diabetes mellitus. Ang II and high glucose are the most important factors that induce proliferation in vascular smooth muscle cell.Resveratrol is a protective polyphenolic compound against cardiovascular diseases and is thought to inhibit cell proliferation.In this study, we investigated the effects of resveratrol on increased cell proliferation by Ang II in high-glucose media, and the inhibition of ERK1/2, Akt and STAT3 proteins phosphorylation which we thought mediate cell proliferation in rat vascular smooth muscle cells.Our results showed that resveratrol inhibits vascular smooth muscle cell proliferation induced by Ang II in normal and high-glucose media. Resveratrol especially inhibits Akt and STAT3 protein phosphorylation which mediate cell proliferation in high-glucose media. Resveratrol, on the other hand, has no inhibitor effect on ERK1/2 phosphorylation induced by Ang II. As a consequence, because resveratrol inhibits Akt and STAT3 protein phosphorylation, our findings indicate that resveratrol could be an effective agent to supress vascular smooth muscle cell proliferation induced by Ang II in high-glucose media.Key Words: Resveratrol, Angiotensin II, Vascular Smooth Muscle Cells