Production of nanofiber designed wound burns cover material with antimicrobial effect

With this thesis, pure silk obtained from silk cocoon will be converted into nanofiber membranes by electrospin technique, and lysozyme and silk polymer have been sprayed together by adding lysozyme to the polymer solution to be spun in order to give the membranes an antibacterial effect. The antimicrobial effect was increased by precipitation of selenium on the silk nanofiber membrane containing lysozyme. In this way, selenium, which has an antimicrobial effect by affecting the peptidoglycan structure of gram-positive cells, but has been reported in the literature to damage the lipopolysaccharide layer due to the lipopolysaccharide layer on the cell wall of gram-negative cells, has been reported to damage the lipopolysaccharide layer, thereby precipitating on the membrane and acting effectively against both gram-negative and gram-positive microorganisms. Wound burn dressing material synthesis was performed. Infections occurring in the wound area delay the healing process of the injured tissue, since conventional wound and burn dressing materials do not have an antimicrobial effect. With the studies carried out within the scope of the thesis, the injured area was isolated by wrapping the injured area with the synthesized membrane like a bandage. In addition, a new material was synthesized to accelerate the healing process by ensuring that the material to be used as a bandage has antibacterial properties.