Synthesis of some hydrazone derivatives, elucidation of their spectroscopic and crystal structures and investigation of their antioxidant properties

M.Sc.THESIS SYNTHESIS OF SOME HYDRAZONE DERIVATIVES, ELUCIDATION OF THEIR SPECTROSCOPIC AND CRYSTAL STRUCTURES AND INVESTIGATION OF THEIR ANTIOXIDANT PROPERTIES Betül AKBAŞ Aksaray University Graduate School of Natural and Applied Sciences Department of Chemistry Supervisor: Assoc.Prof.Dr. MAHMUT ERZENGİN ABSTRACT During the first phase of this research five new hydrazone derivaties called 1-(2-fluoro-3-(trifluoromethyl)benzylidene)-2-(pyridin-2-yl)hydrazine (2F3FMPyH), 1-(2-fluoro-4-(trifluoromethyl)benzylidene)-2-(pyridin-2-yl)hydrazine (2F4FMPyH), 1-(2-fluoro-5 (trifluoromethyl)benzylidene)-2-(pyridin-2-yl)hydrazine (2F5FMPyH), 1-(4-fluoro-2-(trifluoromethyl)benzylidene)-2-(pyridin-2-yl)hydrazine (4F2FMPyH), 1-(4-fluoro-3-(trifluoromethyl)benzylidene)-2-(pyridin-2-yl)hydrazine (4F3FMPyH) were synthesized. The structures of the newly synthesized compounds were determined by X-ray, H-NMR, FTIR, UV-VIS, TGA scans and elemental analysis. In the second phase of this research the synthesized compounds antioxidant activities were compared with the standard antioxidant BHT upon having assayed DPPH free radical scavenging activities. Among those synthesized substances, the 4F3FMPyH molecules has shown to have highest free radical scavenging activity with lowest IC50 value of 2.318 mg/mL. The lowest antioxidant activity has been observedfor the compound 2F3FMPyH. In the same concentration period IC50 value of 1.706 mg/mL has been assessed for BHT. As a conclusion, all the hydrazone derivatives synthesized in this research have shown to cabapable of DPPH free radical scavenging. Keywords : Hydrazon, Free Oxygen Radicals (SOR), Antioxidant, DPPH May,2019; 129 Pages