Metabolic problems occurred after renal transplantation and effects of these problems to patient and graft survival

Uslu B, (2014). Metabolic problems occurred after renal transplantation and effects of these problems to patient and graft survival. Akdeniz University Faculty of Medicine, Department of Internal Medicine, Nephrology Department. Antalya 2014. Introduction: We aimed at this study to determine weight gain and body mass index changes at renal transplanted patients between January 2009 and December 2012 at Akdeniz University Hospital Organ Transplant Center and to determine also whether a relationship between graft patient survival, HLA matching, preemtive or already on dialysis, deceased donors or living donors and dialysis duration or not. Material - methode: This study enrolled 830 patients who had undergone kidney transplantation. Thirty-three percent of patients (274) were women and sixty seven percent were men (556). Patients were between 14-73 years old at transplantation time and average age was calculated 37,5 years. Living donors were seventy eight point one percent (648 patients) and deceased donors were twenty one point nine percent (182 patients). Duration of dialysis ranged from 1 to 252 months (53,1 ± 50,4 months). 199 patients had preemtive renal transplantation. Patients' body mass index, eGFR values, blood pressure values were classified according to the graft survival. C-reactive protein levels were taken inflammatory parameters. Results: Body mass index and weight were significantly higher at 0, 6, 12 and 60. months at patients developing diabetes compared to nondeveloping diabetes (p<0,001). We observed that weight and body mass index are risk factors for development of diabetes. As an indicator of inflammation, C reactive protein and albumin –as a negative acute phase reactant- were eveluated at patients with graft loss and without graft loss. CRP levels were higher and albumin levels were lower at patients with graft loss compared to without graft loss (p<0,001). Conclusion: A high levels of body mass index at pre-transplant and post-transplant period is a risk factor for development of diabetes and a high level of inflammation is risk for graft loss. Key words: renal transplantation, body mass index, C reactive protein, albumin levels, graft survival