Dynamic modeling of human cardiovascular system and an axial heart pump

Engineering applications are widely used in modern medicine with the progress of technology. Heart pumps are an example to those engineering applications which is used for treatment of cardiovascular system diseases. In this thesis a numerical human cardiovascular system model that includes heart chambers, heart valves, systemic arteries, systemic veins, pulmonary arteries and pulmonary veins was developed. Diseased human cardiovascular system model was obtained by adjusting the parameters of the healthy cardiovascular system model. Numerical models were developed for two types of heart pumps (Heart Turcica axial and Heart Turcica centrifugal). Heart Turcica axial model includes the dc motor dynamics. These models were integrated to diseased human cardiovascular system. Simulations were performed to assess the boundary operating speeds of heart pumps which causes different physiologically significant pumping states. Also pulsatility indexes were defined for pressure difference across the pump, pump flow rate and motor current. These pulsatility indexes are calculated for increasing operating speeds. Studies on control of the pressure difference across the pump and control of pump flow rate were also done.Based on the findings it has been concluded that Heart Turcica axial and Heart Turcica centrifugal may provide sufficient pressure and flow required for the perfusion blood for the tissues.