Eklem kıkırdağı tedavisi için 3b metilselüloz - Jelatin doku iskelelerinin üretimi ve karakterizasyonu

Articular cartilage is a highly specialized tissue that plays a crucial role in movement. However, its avascular nature severely limits its regenerative capacity, often resulting in degenerative diseases. Current treatment methods face challenges such as prolonged recovery times, inconsistent outcomes, and high costs. This study aims to develop scaffolds that mimic the properties of natural cartilage, as to be an alternative. For this purpose, Methylcellulose(MC)-Gelatinbased tissue scaffolds were fabricated with varying MC(10%, 12.5%, and 15%) and constant gelatin(20%) concentrations using a 3D printer. Characterization studies were performed to evaluate scaffold performance. Fourier Transform Infrared (FTIR) spectroscopy was employed to analyze the chemical interactions between MC and gelatin, particularly the effects of MC concentration. Contact Angle Measurement (CAM) results indicated that increasing MC concentration enhanced hydrophobicity due to the amphiphilic nature of MC. Mechanical tests revealed that increasing MC concentrations led to higher elasticity but reduced stiffness. Swelling and degradation tests revealed that higher MC concentrations reduced degradation rates and enhanced scaffold durability. In conclusion, the produced tissue scaffolds were able to mimic natural cartilage tissue closely, especially 10MC scaffolds stand out as a promising candidate to be a treatment alternative.