Evaluating the effects of biomarkers crp, procalcitonin, galactomannan and blood group on prognosis in patient with febrile neutropenia

Aim: Febrile neutropenia is one of the most important factors responsible for the morbidity and mortality in oncologic patients. The aim of this study is to evaluate the effects of biomarkers like CRP, Procalcitonin (PCT), Galactomannan (GAL) and Blood Group on Prognosis in patient with febrile neutropenia. Methods: In this study, a total of 102 patients diagnosed with febrile neutropenia, consisting of 69 men and 33 women who are 18 years or older were recruited. İn total, 192 febrile neutropenia events were evaluated and analyzed. The patients were classified as low or/and high-risk according to their massc scores. İn addition, the prognosis of patients were statistically compared according to their cisne scores. The data of the study were analyzed with the statistical package for social sciences (spss) version 18.0. p<0.05 was considered statistically significant. Results: The mean age of the patient was 55 years and 67.7% of the patients were below 65 years old. Of the patients, 67.2% were men, 32.8% were women. The average duration of discharge and duration of neutropenic fever (nf) in patients were 27.8 days and 13.8 days respectively. The discharge time for 26 days or more is 12.707 times more in patients with NF times of 12 days or more than other patients. The discharge time of all-diagnosed patients was longer than that of the other patients. There were no relationship between initial crp, pct, gal and discharge and nf times. The gal and pct values were higher in patients who developed bacteremia. The high level of galactomannan is correlated with the use of piperacillin-tazobactam. Examining the pct values on an average of 17.2 days after fna can be used to predict the severity of infection and hospitalization. Although it appears that crp has no effect in predicting bacteremia and prognosis, it can be used as a biomarker to predict the long-term hospitalization in fna patients by examining them once in every 6-7 days on average. Patients who recieved prophylactic antibiotics and antifungals have longer hospipalization compared to those who did not. There was no significant recovery in patients who took antibiotics and antivirals as prophylaxis; and also there was no significant relationship between the use of antifungals and overall survival. There was no relationship between discharge and nf times in both the dead and the survivors at the and of the treatment. There was no relationship between mascc and cisne scores with discharge and nf times. Conclusion: Nf time directly affected the discharge time. The discharge time was long in the patient with long nf time. There was no relationship between initial crp, pct, gal, blood group, massc and cisne scores with discharge and nf times. High levels of pct may be a prodrome of bacteremia. The crp and plt values viewed at certain time intervals can predict the long duration of hospitalization. Cost efectiveness analyses of antibacterial, antiviral and antifungal prophylaxis are needed. Keywords: Febrile neutropenia, Discharge time.