The importance of the mean platalet volum in subcli̇ni̇cal intraamniotic infecti̇on diognosi̇s and follow up of the premature preterm rupture of membranes

Objective: This study was carried out in order to determine the role and importance of MPV for diagnosis and follow-up of sub-clinic infections in PPROM, and to compare to the values of ProCT , CRP and WBC . Method: This study is a case-control type of study. The study group consists of 38 patients diagnosed for preterm rupture of membrane between 24th and 34th gestational weeks, while control group consists of 43 healthy pregnant women between 24th and 34th gestational weeks. WBC, ProCT, CRP and MPV values of patients at the moments of diagnosis and delivery and the WBC, ProCT, CRP and MPV values of women in control group, which were measured at any moment, were recorded and compared. Moreover, the placental pathology reports of study group were examined, and the WBC, ProCT, CRP and MPV vales of those having chorioamnionitis and those of cases having no chorioamnionitis were compared to each other. Results: Of the study group, the WBC (17.01 ± 4.82), CRP (1.15 ± 0.74), and ProCT (0.08 ± 0.05) values measured before the delivery were significantly higher than those measured at the moment of diagnosis. Of the study group, the WBC (11.97 ± 2.59) and CRP (0.48 ± 0.29) values measured at the moment of diagnosis were statistically significantly higher than those of control group. Prenatal WBC (17.01 ± 4.82), CRP (1.15 ± 0.74) and ProCT (0.08 ± 0.05) values of patients were statistically significantly higher than those of control group. Moreover, in study group, the CRP (1.73±0.67) values of patients with chorioamnionitis were found to be statistically significantly higher than those of patients having no chorioamnionitis. When compared between study and control groups, no significant relationship was found between MPV values of the groups. Discussion: Prenatal WBC, ProCT, CRP and MPV values of patients in PPROM group were found to be significantly higher than those values measured at the moment of diagnosis and those values measured among control group cases and, thus, the WBC, CRP and ProCT can be interpreted to be capable of diagnostically predicting the intrauterine infection. A statistically significant relationship was found between prenatal CRP values of patients in PRM group and the values measured among the cases with histopathologic chorioamnionitis. For this reason, in clinic observation, CRP may be more useful than WBC and ProCT. No statistically significant relationship was found between MPV and diagnosis and follow-up of sub-clinic infection in PPROM. Keywords: preterm premature rupture of membranes, mean platelet volume, chorioamnionitis, sub-clinic intraamniotic infection