Hepatoselüler karsinoma gelişim ve metastazında mikrornaların rolü

Autophagy is a cellular stress response mechanism whose activation leads to the degradation of proteins as well as damaged organelles for maintaining cellular homeostasis. Autophagic capacity or alteration of its activity was found to relate with several pathologies, including cancer and metabolic diseases. Besides, microRNAs (miRNAs) have implicated in several fundamental biological processes such as cellular transformation, carcinogenesis, and even autophagy. Deregulation of both autophagy and miRNA pathways have found to contribute to the pathogenesis and progression of hepatocellular carcinoma (HCC), which is one of the mortal types of cancer. Deregulation of autophagy-regulating miRNAs addressed almost all stages in HCC tumorigenesis from manifestation of low-grade dysplastic nodules to advanced disease. Thus, manipulation of autophagy by miRNAs might provide novel targeted therapy options for HCC.