Does hypothermia alter the effectiveness of sugammadex an experimental study

Hypothermia, described as body tempature below 35°C, is caused because of the imbalance of the production and loss of heat. It can occur spontaneously as well as constituted therapeuticly.Hypothermia effects many organs and systems. In hypotermic conditions, due to decrease of hepatic and renal blood flow, enzymatic biotransformation and excretion of drugs delay. Thus, duration of action enhance in many drugs.Sugammadex is a novel compound which designed as an antagonist of steroidal neuromuscular bloker agents, and an alternative to neostigmine for the safety advers effect profile.This study was planned to evaluate the effect of hypothermia on sugammadex and was performed by 40 female Wistar-Albino rats, weightining 300-400 gr, provided from Akdeniz University Faculty of Medicine Laboratory of Experimantal Animals. Animals were divided into two groups. Hypotermia was achived by using blanket in the first group. The second group was normothermic.NM blokage was performed by 1,2 mg/kg rocuronium in all animals. Sugammadex in 4 mg/kg doses was given when the PTC=2.In comparison to normothermic group, in hypothermic group, the time for sugammadex, TOF=0, TOF=4, TOF>75% and PTC=2 were significantly higher.In conclusion; the effect of sugammadex was enhanced in hypothermia. It could be a result of decrease in renal blood flow as a decline in excretion of drug, besides the delay of forming complex with rocuronium.