DoktoraAçık Erişim

Homeostazın termodinamik yönü

2023
0 görüntülenme
0 i̇ndirme
Danışman: Prof. Dr. Mustafa Özilgen ; Prof. Dr. Bayram Yılmaz

Özet (EN)

Organisms sustain themselves at far-from thermodynamic equilibrium with their surroundings. The living organisms import energy and exergy, and export entropy to maintain constancy of their vital internal physiological components via homeostasis. Living systems generate entropy by reason of metabolic activity, the greatest amount of entropy is exported, whereas only a small amount of fraction accumulates. Accumulation shows itself as structural diminishing, considered an indication of ageing and measured as an information entropy. The entropic age theory implies that metabolic heat harms the living systems in the long term and leads to ageing. The term 'human superorganism' refers to the human host and the millions of microorganisms residing in and on the host. The gut microbiota plays a crucial role as an autonomous thermodynamic subsystem. It can generate and export entropy without age-related impairments. Thermodynamic analyses must be conducted to understand the entropy generated by the host and the gut. These analyses can help us quantify the entropy generation of both the host and the gut microbiota. This understanding is essential for understanding the role of the gut microbiota in the human superorganism. In recent years, research into the role of gut microbiota in human health and ageing has grown. This study has suggested that a large proportion of the metabolic entropy of the human superorganism, ranging from 12% to 59%, is generated by gut microbiota. This is exported with faeces without contributing to host ageing. This suggests that the gut microbiota could be a major factor in an individual's longevity. Although the gut microbiota has traditionally been studied for its nutritional benefits to the host, this newly hypothesised benefit to longevity needs to be studied further. This research could have implications for dietary and lifestyle interventionsthat increaselifespan expectations.The relationship between athletes' lifespan expectancies and the sports they are involved in can be explored through the entropic age concept. Previous nutrition studies have shown success with this method. To further investigate the relationship between athlete longevity and nutrition, athletes' caloric needs must be considered when designing diets for each athlete group. It is imperative to adhere to the latest guidelines when planning diets for athletes, as their caloric needs vary depending on the type of sport they participate in. Additionally, athletes must be given proper nutrition to perform at their peak and remain healthy and injury-free. By doing so, athletes' lifespan expectancies can be improved and they can continue to pursue sports activities. This study suggests that athletes may extend their longevity significantly if they adjust their diet following retirement at 50. The predicted average longevity for male athletes was 56 years for cyclists, 66 years for weightlifters, 75 years for rugby players and 92 years for golfers. If they start consuming the retirement diet after 50 years of age, the life expectancy of the cyclists may increase for 7 years, and those of weightlifters, rugby players and golfers may increase for 22, 30 and 8 years, respectively. This demonstrates the impact of dietary change on life expectancy and suggests that athletes should not neglect their diet even after retirement. Athlete nutrition is crucial to sustaining the body's health status. Low-energy availability causes physiological dysfunction and a shorter lifespan. High-calorie intake and extreme caloric restriction diet decrease the longevity of athletes. Athletes should maintain energy balance in the body.

Yazar

Dr. Cennet Yıldız

Bu Yayına Nasıl Atıf Yapılır

Cennet Yıldız (Doctorate thesis). Homeostazın termodinamik yönü, 2023, Yeditepe University.

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