Kendiliğinden bir araya gelen peptit nanofiberlerden oluşan jellerin enzimatik degredasyonu

The self-assembled peptide nanofiber gels have received enormous attention because of their inherent biocompatible, biodegradable and functional properties. They provide a smart platform for a range of applications such as tissue engineering, drug delivery and wound healing. These gels are formed through noncovalent interactions such as hydrogen bonding, hydrophobic interactions and electrostatic interactions among the peptideamphiphile molecules at physiological conditions. In order to understand thestability of these gels in the presence of proteases in natural conditions, we studied degradation behavior of the gels with proteinase K, which is anonspecificprotease cleaving the peptide bonds. Degradation process was studied by measuring weight measurement and TEM imaging. In addition, sustained releaseof Rhodamine B from these gels was also studied in the presence of proteases.The results clearly demonstrated that presence of D- amino acids in the peptide release profile of the encapsulated molecules in the gels. These findings are interesting for biomedical applications of these materials dueto their tunable degradation and controlled release behavior