Kombine kanser tedavisi için altın ​​nanoçubukların ve kemoterapi ilaçlarının plga nanopartiküllerine ikili enkapsülasyonu

Due to its multifaceted nature, cancer often requires combination therapies for effective treatment. In this study, we report the development of a dual functional nanoplatform in which gold nanorods (AuNRs) and doxorubicin (DOX) are co encapsulated within poly(lactic coglycolic acid) (PLGA) nanoparticles (≈246 nm). The miniemulsion-based formulation produced nanoparticles with a narrow size distribution (PDI ≤ 0.1), a DOX loading of 32±4 µg/mL, and 47% AuNR encapsulation efficiency. AuNR encapsulated PLGA nanoparticles retained their structural integrity, shape, and longitudinal surface plasmon resonance (LSPR) properties during 110-day storage at 4 ◦C. Upon near-infrared laser irradiation (808 nm, 1W/cm2, 5 min), nanoparticles generated a temperature increase of approximately 25 ◦C, confirming preserved photothermal performance. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assays in MCF-7 breast cancer cells revealed that cytotoxicity was primarily driven by the DOX payload, with no statistically significant synergy observed between chemotherapy and photothermal effects.