Effects of geraniol to rat tissues induced lead

In this study, it was aimed to investigate the protective effect of geraniol against oxidative stress produced by lead acetate in rats. For the study, four different groups as control group (C), lead acetate (LA) group, geraniol (G) group and lead acetate + geraniol (LA + G) group were formed. MDA, reduced GSH and various minerals levels and AChE, GST, CAE activities were determined in the liver of rats. According to the results, MDA level was significantly increased in LA group compared with C group (p<0.001) whereas MDA level was significantly decreased in LA+G group compared with LA group due to effect of geraniol (p<0.01). There was no statistically significant difference in the reduced-GSH levels of all treatment groups compared to the C group, although a relative decrease in the GSH level of the LA group compared to the C group was observed. AChE, GST and CAE enzyme activities were significantly decreased in the LA group compared to the C group (p<0.01; p<0.001). It was also determined that the lead level was significantly increased in the LA group compared to the C group and significantly decreased in the LA + G group compared to the LA group (p<0.001). As a result, it has been concluded that geraniol as an antioxidant against oxidative stress induced by lead acetate has a positive effect and selected biochemical markers are useful for such studies.