Medikal uygulamalar için tulyum laser sistemi tasarimi ve gel“iştirilmesi

The Thulium (Tm:YAP) laser is suitable for medical applications due to strongabsorption in water. In this thesis, a computer controlled Tm:YAP laser system witha power output up to 1 W and emission wavelength of 1980 nm were established.Once the laser system was stabilized, its output power, spot size, and light intensitymeasurements were performed. The thermal effects of the laser system on brain, liver,heart, and kidney tissues were macroscopically analyzed. The ablation efficiency ofthe laser system was experimentally tested on ex-vivo brain tissue. The maximumablation efficiency was obtained at a power level of 200 mW with a duration of 10seconds (69 W/cm2). The fluence effect for skin ablation was analyzed by histology onWistar rat skin tissues during a 4-day healing period. Temperature measurements bythermal camera and thermocouples were investigated to see the temperature effect ofCW and modulated mode of the Tm:YAP laser under skin and on skin surface. Thetemperature increase was faster and the temperature decrease was found slower in CWmode. The main aim of the study is to explore the welding capabilities of Tm:YAPlaser in modulated and CW modes of operation on Wistar rat skin during 21-dayhealing period. Full-thickness incisions were welded at 100 mW and 5 s (34.6 W/cm2).The results were compared to conventional suture techniques by both histology andtensile strength measurements. After day 4, full closure was obtained for both lasermodes, whereas, full closure was not observed till day 4 in suture group. In tensilestrength analysis, tensile forces found for both modulated and CW modes of operationwere significantly higher than the tensile force values found for conventional suturetechnique. Tm:YAP laser tissue welding possessed significantly stronger closure thanconventional suture technique.