Investigation of synthesis and biological activities of some diet derivatives by microwave method

In this thesis, by using microwave method, 8 Schiff base derivatives were synthesized in different structure resulting from condensation of cinnamaldehyde and paramethoxy cinnamaldehyde with various amine derivatives. The synthesis of N- (4-methoxy cinnamyliden) -2-bromoaniline, N- (4-methoxy cinnamyliden) aniline, N- (cinnamylidene) -4-bromoaniline synthesized firstly by microwave method, N- (4-methoxy cinnamylidene) -4-fluoroaniline, N- (4-methoxy cinnamylidene) -3-chloro aniline, N- (4- 4-bromoaniline, and N- (cinnamyliden) aniline compounds in the microwave synthesized literature were synthesized. The compounds were characterized by FTIR spectroscopy, NMR spectroscopy and elemental analysis method. The antibacterial activities of the synthesized compounds were investigated. Two bacteria (Acinetobacter calcoaceticus strain and Pediococcus acidilactici) were studied. It was determined that each of the 8 Schiff bases was bound to the bacterial cell wall and destroyed its structure and inhibited bacterial growth. In addition, the inhibitor effects of these compounds on the hydratase activity of hCA-I and hCA-II isoenzymes were investigated and IC50 values were calculated to have stronger inhibitory effects than the reference inhibitor acetazolamide.