Effect of slimming diet and pharmacological treatment on weight loss and some blood parameters in morbidly obese people

This study examined the effects of two slimming diets with different fat content (25-30% of the energy and a low-fat diet with 20-24% of the energy coming from fat) applied to morbidly obese individuals, and the combination of pharmacological treatment and diet on some important blood parameters, especially weight loss. It was planned and carried out to reveal its effects. The study was carried out at Gaziantep University Şahinbey Research and Application Hospital Endocrinology Polyclinic. 63 morbidly obese (Body Mass Index > 40 kg/m2) individuals between the ages of 18-65 participated in the study within 3 months, which is the duration of this study. A survey form was applied to determine the demographic characteristics and nutritional habits of all individuals participating in the research. To evaluate the nutritional status, a food consumption record, a food consumption frequency form, a nutrition knowledge level scale (YETBİD) prepared for adults was used to measure basic nutrition and food-health knowledge levels, and a physical activity form was used to determine the physical activity level. Morbidly obese individuals were randomly divided into three groups. 1st group (n=21); standard diet treatment, group 2 (n=21); standard dietary treatment + pharmacological treatment, group 3 (n=21); received low-fat (20-24% fat) diet treatment + pharmacological treatment. At the end of the three-month study, the groups (1st, 2nd, and 3rd Group) respectively (1st, 2nd, and 3rd Group) lost 8.7% (94.97 ± 6.81 from 104.1 ± 7.15 kg), 11.3% (105.3 ± 8.59 kg). (93.47 ± 7.67 kg from 93.47 ± 7.67 kg), 12.9% (93.04 ± 8.84 from 106.81 ± 10.26 kg) body weight loss (p<0.05). The decrease in waist and hip circumference between groups was found to be statistically significant (p<0.05). The weight loss in the third group was higher than the others. The decrease in some blood parameters such as fasting blood glucose (mg/dL), total cholesterol (mg/dL), LDL - cholesterol (mg/dL) decreased at a statistically significant level in all groups, and there was no difference between the groups in this respect (p < 0.05). If lifestyle changes and an individually planned diet program do not yield acceptable results in the treatment of obesity, pharmacological treatment may be considered.