The effects of proliferation, apoptosis and angiogenesis on prognostic factors and survey in renal cell carcinomas

Renal Cell Carcinomas ( RCCs ) are the most commonly seen renal tumors in adults. Although patological stage and nuclear degree of the tumors are considered as the most important prognostic factors, due to the heterogenity seen in RCCs, there might be seen different survival rates among the patients who have the same stage. For this reason, we need to find out new prognostic factors in RCCs. In our research, we?ve investigated different prognostic factors such as proliferation, apoptosis and angiogenesis and their interactions with each other.All 40 RCC specimens have been worked in paraffin embedded tissues. The informations of patients such as age, sex, histological types, Fuhrman?s grade, TNM stage have been recorded. p53, Ki-67, CD34, bcl-2, EGFR, VEGF, and NF-KB stains have been performed immunohistochemically. Known prognostic factors, survivals and their interactions of all immunohistochemical indicators have been evaluated statistically.According to our findings in 40 specimens, 32 clear cell, 6 papillary cell and 2chromophobic cell RCC were observed. Mean survival rate of the patients was 12,5 months. Significant relationship has been determined between NF-?B with p53 (r: 0,410, p=0,009) bcl-2 ( r:0,509,p=0,001), VEGF ( r:0,516, p=0,001), EGFR ( r:0,410, p=0,009 ). None of the immunuhistochemical indicators has been found to be effective to show survival rates. Among the parameters worked on, only the size of the tumor has been shown to be an independent prognostic factor.According to the results of this study, we have not been able to find out a new prognostic factor to show survival rates in RCCs which had been know with a high vascularization and and chemoterapeutic resistance. However, our results for NF-?B which has been recently studied extensively have given some new findings in terms of its function in RCCs. Determinig the effect of various molecules such as NF-?B, with limited information in RCCs, and demonstrating its relation with different factors will provide new developments in RCC management in terms of a prognostic factor effective on survival.