Evaluation of diabetes mellitus risk measures of death after kidney transplantation

Introduction and Aim: Posttransplantation diabetes mellitus (PTDM) is an important risk factor for cardiovascular complications and mortality and is closely associated with graft loss, infections and increased costs. Our study aimed to investigate the impact of various risk factors on the development of diabetes in patients who visited the renal transplant polyclinic of our hospital and had no history of diabetes prior to transplantation. Materials and Methods: Our study included 202 patients who received a renal transplant and applied to Samsun Ondokuz Mayıs University, Department of Nephrology, transplant polyclinic. None of these patients had been diagnosed with diabetes before their transplantation. 93 patients who developed diabetes after transplantation and 109 patients who didn't developed diabetes after transplantation had their risk factors compared and their effects examined in a retrospective study, Results: In our study, of the group that developed PTDM 61.3% were male, the mean age was 54.31±10.08 years, the mean age of transplant was 46.14±11.12 years, which was statistically significant (p<0.001). Patients who had diabetes and those without diabetes were significantly different in their kinship status and their causes of CRF (p<0.001, p=0.038). Obesity was present in 12.8% non-diabetic patients and 28% of diabetic patients, and the difference in the prevalence of obesity was statistically significant (p<0.012). A statistically significant difference was found between patients with and without diabetes when hypomagnesemia and preoperative IGT were compared (p<0.001). While the HbA1c level was above 5.7% in 68.3% of the patients who developed diabetes, the HbA1c level was above 5.7% in 16.8% of the patients who did not develop diabetes, which was found statistically significant (p<0.001). Conclusion: PTDM risk factors (age, transplant age, donor consanguinity, primary kidney disease cause, presence of hypomagnesemia, presence of preoperative IGT, HbA1c level) detected in our patients are similar to the literature. These risk factors can be considered when planning the diagnosis, follow-up, and treatment of patients to reduce the number of mortality and morbidity.