Investigation of synthesis and properties of tiyazolamin-Schiff bases

In this work, a novel aminothiazole which was not synthesized before reaction of 1,3-dichloroacetone with thiourea was synthesized and its structure was elucidated by FT-IR and 1H, 13C-NMR, single crystal X-ray diffraction methods. New Schiff bases were derived by synthesizing 4,4'-disulfanediylbis(methylene)dithiazol-2-amine with benzaldehyde derivatives. A series of compounds containing thiazole, disulfide bridge, and imine group, which are also found in the structure of many synthetic or natural drugs, were synthesized and the structures were illuminated by FT-IR and 1H-NMR.