Determination of the carbonic anhydrase and cholinesterase enzyme inhibition potentials of some new synthesis sulphonamide derivatives

Human carbonic anhydrase isoenzyme I and II (CA I and II) inhibitors, glaucoma, cancer, etc. They are considered important therapeutic agents due to their potential to be used in the treatment of diseases. Inhibition of cholinesterases (ChEs), namely acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), has been considered the most effective treatment approach for Alzheimer's disease (AD) to date. In this study, a series of new Schiff base derivatives containing sulfonamide groups were synthesized. Characterization of the synthesized molecules was done using elemental analysis and some spectroscopic methods such as FTIR, 1H- and 13C-NMR. All molecules synthesized against these four esterase enzymes showed strong effects. As a result, it can be said that some synthesized Schiff base sulfoamide derivatives may be new potential drug candidate molecules due to their strong inhibitory activities at the nanomolar level against the enzymes used in this study.