Investigation of epidemiological, laboratory and clinical particulars of liver cirrhosis patients who apply to the Medical faculty of İnonu University between 2010-2016

510 patients diagnosed with liver cirrhosis who were referred to İnönü University Turgut Özal Medical Center gastroenterology polyclinic were studied and the frequency of epidemiological, laboratory and clinical data of liver cirrhosis was aimed in our study. The ages of our patients ranged from 18 to 86 years and the mean age was 54,21 (± 14.76). 327 (64,1%) of the patients were male and 183 (35,9%) were female. When analyzed in liver cirrhosis etiology 227 (44,5%) Hepatitis B Virus (HBV), 60 (11,8%) hepatitis C virus (HCV), 17 (3,3%) chronic alcohol use, 11 (2,2%)Budd's Chiari syndrome, 9 (1,8%) otoimmun hepatitis, 8 (1,6%) HBV+HCV, 8 (1,6%) Wilson's disease, 4 (0,8%) hepatosteatosis, 3 (0,6%) HBV + Hepatitis D Virus (HDV), 3 (0,6%) primary biliary cirrhosis (PBS), 2 (0,4%) hemokromatozis, 1 (0,2%) primary sclerosing cholangitis (PSK) , 1 (0,2%) Gaucher disease and 1 (0,2%) alpha-1 antitrypsin deficiency were determined. No etiological cause was found in 155 patients (30,4%), and these patients were identified as cryptogenic liver cirrhosis. In clinical trials, 384 patients (75,3%) had decompensated cirrhosis and 126 patients (24,7%) had compensated cirrhosis. When we examined the complications of liver cirrhozis, it appeared that there were ascites in 302 (59,2%) patients, furthermore we observed that there were grade 1 esophageal varices in 98 (19,2%) patients, grade 2 in 84 (16,5%) patients and grade 3 in 61 (12%) patients. We hadn't known esophageal varices grade in 152 (29,8%) patients. Portal vein thrombosis in 42 (8,2%), esophageal variceal bleeding in 29 (5,7%), hepatic encephalopathy in 27 (5,3%), spontaneous bacterial infection in 9 (1,8%), hepatorenal syndrome in 6 (1,2%) was detected. Hepatocellular carcinoma (HCC) was detected in 97 patients (19%). Antiviral therapy was given to 165 (32,3%), enzyme therapy to 1 (0,2%) and immunsupressive therapy to 6 (1,2%) of the 510 patients. 338 (66,3%) were follewed without treatment. Liver transplantation was performed in 170 patients (33,3%). No etiologic cause was found in 30,4% of the patients. In conclusion, viral factors were the most common cause of etiology in liver cirrhosis. HBV was the most common cause of the viral factors.