3,4-dimethyl phenol mannich bases of phenolic synthesis and characterization of amines by microwave method

In 1912 after the Mannich reaction was discovered by Mannich and Krosche it was used in process of synthesis in variety compounds. Mannich reaction is occured in a compound which carries active hydrogen, in formaldehyde and with the existance of 10 or 20 amine. That occured compound is called Mannich Base.The Mannich Base that was occured is used in decontamination of water / waste water / mud processes, in polymer, petroleum, cosmetic, painting industryes, in pharmacy sector, in food business and textile industry.In this investigatien, the Mannich Base was synthesized was 2-((dibenzylamino)methyl)-4,5-dimethylphenol, 2-((dimethylamino)methyl)-4,5-dimethylphenol, 2-((4-flurophenylamino)methyl)-4,5-dimethylphenol and 2-((ethylamino)ethyl)amino)methyl)-4,5-dimethylphenol with the microwave method which is short and effective method. Structures of synthesised compounds were identified by using 13C-NMR, 1H-NMR, IR, TG/DTA and elemental analysis methods.The biological activities of that synthesized compounds were examined. According to result of that examine it is it is observed that 2-((dimethylamino)methyl)-4,5-dimethylphenol showed activity.Key words: 3,4-Dimethyl Phenol, Mannich Base, Ligand, Microwave, Biological activity