The synthesis of new heterocyclic compounds containing cycles of 3-(4-chlorobenzyl)-5-(4-chlorophenyl)-1h-1,2,4-triazole and 5-(4-chlorobenzyl)-2-undecyl-2,4-dihydro-3h-1,2,4-triazol-3-one

In this study, some 4-amino-1,2,4-triazole derivatives (37, 60) were synthesized starting from hydrazones (35, 36). Schiff bases (38-40, 61-65) were obtained from the reaction of synthesized compounds (3) with appropriate aldehydes. 42 and 66 as starting compounds were synthesized by deamination of compounds (37, 60) in the presence of hypophosphorous acid and sodium nitrite. Treatment of compounds (42, 66) with ethyl bromoacetate obtained ester derivatives (95, 97), which was converted to the acetohydrazide derivatives (96, 98) by treatment with hydrazine hydrate. The condensation of 96 with CS2 in the medium of KOH, followed by cyclization with hydrazine hydrate, afforded (130). Treatment of 130 with several aldehydes gave Schiff bases (131-135), which were converted into Mannich bases (226-230) in the presence of 1-phenylpiperazine. Hydrazide-hydrazones (99-108) and thiosemicarbazides (176-185) were synthesized from acetohydrazides (96, 98). The cyclization of thiosemicarbazides (176-185) in the presence of NaOH resulted in the formation of 1,2,4-triazol-3-thiol derivatives (186-195) which were converted into Mannich bases (243-249) in the presence of formaldehyde. Newly obtained compounds were characterized by IR, NMR, Mass spectra and elemental analysis. All the compounds were examined for their antimicrobacterial and antilipase activity.