Association between leptin and nesfatin-1 with antioxidant capacity in obese Iraqi patients

This study was involved the exploration of nesfatin-1 and leptin association with the total antioxidant capacity (TAC) in obese males. The experimental part of the study has involved the analyze of nesfatin-1, leptin, TAC, triacylglycerol (TAG), total cholesterol (T.Ch), high-density lipoprotein-cholesterol (HDL-Ch), low-density lipoprotein cholesterol (LDL-Ch), very low-density lipoprotein-cholesterol (VLDL-Ch), urea, and creatinine in 60 obese males, and controlled with 60 lean males of comparable ages. Anthropometrics for obesity were calculated for all of the selected subjects including body mass index (BMI), waist circumference (WC), waist to hip ratio (WHpR), and waist to height ratio (WHtR). The results have expressed a significant (P<0.05) higher level of leptin with significant (P<0.05) lower levels of nesfatin-1 and TAC in obese males compared to lean males. Additionally, TAG, T.Ch, LDL-Ch, VLDL-Ch, and urea were greatly (P<0.05) higher in obese males than lean males, while HDL-Ch was greatly (P<0.05) lower. The differences in creatinine were non-significant (P>0.05). Leptin was associated directly with BMI and inversely with nesfatin-1 in obese males. On the other hand, nesfatin-1 was associated directly with TAC, and both were associated negatively with BMI in obese males. In conclusion, nesfatin-1 has important role in obesity condition, and it involved in the oxidative stress that developed in obesity.