Influences of genetic changes on the success of serum irrigating radiofrequency ablation in patients who have atrial fibrillation and mitral valve disease

Serum irrigating radiofrequency ablation (SIRFA) is one of surgical techniques can be applied for the treatment of atrial fibrillation (AF) with confidency and it?s success is associated with in the some certain factors. In this study, minK S38G gene and ACE gene polymorphisms? role were investigated in the success of SIRFA surgery.Between September 2003-August 2008 patients with valve disease and applied SIRFA and valve surgery with the diagnosis of AF, under 60 years of age, left atrial diameter is less than 6 cm, and without CAD were studied. After SIRFA surgery, with 30 patients have sinus rhythm were classified as group I, 30 patients with continued AF as group II, 30 patients with preoperative valve disease in sinus rhythm as a control group (group III) 5 cc venous blood taken into EDTA tubes for the DNA analysis, mink S38G gene and ACE gene polymorphism analysis standardization were performed at genetic laboratory.The mean age was 48.74±10.07 years respectively. Demographic findings were similar between groups. As a result of the studies done on the MIN K 38G allele, in patients with GG genotype SIRFA success was lower (p<0.03). With ACE gene, in patients with I / D genotype , SIRFA success was lower but not statistically significant. (p<0.38). Left atrial thrombuses were more in AF group and this situation is revealed on the low success of SIRFA (p<0.01).In people with the ACE gene I / D genotype and minK gene GG genotype known to be associated with AF, SIRFA success is reduced, but in individuals with minK gene GG genotype SIRFA success was reduced statistically significant.We considered that the factors in reducing SIRFA surgery success, genetic factors should be evaluated.