Determination of plasma cholecystokinin levels in patient with migraine without aura

Migraine is a type of a headache that lasts 4-72 hours, accompanied by nausea and vomiting, manifested by recurrent moderate or severe attacks. Hormonal, environmental and genetic factors play an important role in migraine sensitivity. The complicated condition of migraine pathophysiology is still not completely understood. However, in studies it is considered that some vasodilator agents are effective in migraine formation. Therefore, we researched the migraine effect of cholecystokinin, a neuropeptide with vasodilator effect. The aim of this cross-sectional and descriptive study is to examine whether there is a difference between plasma cholecystokinin levels in patients with migraine without aura and in migraine-free patients. Thirty-six migraine patients who were diagnosed as Migraine without aura by Düzce University Application and Research Center Neurology Policlinic were enrolled in the study, addingly, thirty-seven patients who were not migraine patients and referred to other outpatient clinics of the hospital participated in the study as a control group.The patient information form was used as the data collection tool and the blood samples were taken from the participants and examined in the laboratory environment. The obtained data were evaluated by consulting with a statistical expert on a computer using SPSS 22.0 program. Participants' sociodemographic characteristics, medical history, vital signs, and knowledge of migraine were assessed by descriptive statistics (percent, number, mean). In the comparative analyzes of the migraine group and the control group, the X² test was used in the comparison between the subgroups, and the Mann Whitney U and Kruskal Wallis test, which was recommended as a non-parametric test, were used in the comparison between the averages. In the statistics p confidence interval for p significance was accepted as p≤0.05. The mean age of the migraine group was 35,53 ± 6,83, the mean age of the control group was 34,99 ± 7,79, and the total group mean age was 35,23 ± 7,29. When the cholecystokinin (CCK) values of the migraine group and the control group were compared, the CCK value of the migraine group was found to be 1,83 ± 0,60, while the CCK value of the control group was 1,73 ± 0,49. Keywords: Migraine, Cholecystokinin, Headache, Neuropeptide, Cerebral vasodilatation