Böbrek hücreli karsınomda ACTR3 gen ekspresyonunun analizi

Renal cell carcinoma (RCC), in particular, is a major health concern that is becoming more commonplace worldwide. Developing targeted therapeutics requires an understanding of the molecular pathways behind the disease's etiology. The Actin-Related Protein 3 (ACTR3) gene has drawn interest among the many genes linked to kidney cancer because of its possible involvement in tumor growth and disease progression. A crucial component of the actin-related protein (ARP3) group, ACTR3 is involved in a number of biological processes including intracellular transport, cytoskeletal dynamics, and gene expression regulation. The purpose of the study is to compare the role of ACTR3 gene expression level between renal cell carcinoma tissue and control renal tissue. Quantitative Real-time polymerase chain reaction (qRT-PCR) was employed in the study to analyze gene expression. The study analyzed gene expression levels by examining ten renal carcinoma tissue samples and ten corresponding control renal tissue samples, both collected from the same group of patients using quantitative Real-time polymerase chain reaction (qRT-PCR). The research demonstrated a fold change with 1.147 in ACTR3 gene expression in kidney cancer tissue samples relative to normal kidney tissues; however, this increase did not meet statistical significance, since (p = 0.578). Therefore, we think that more research using larger sample sizes is necessary to examine and comprehend the connection between kidney cancer and ACTR3 expression levels.