Böbrek kanserinde actr2 gen ekspresyonunun belirlenmesi

Kidney cancer, particularly renal cell carcinoma (RCC), poses a significant health challenge globally, with its incidence steadily rising. Understanding the molecular mechanisms underlying its pathogenesis is crucial for developing targeted therapies. Among the multitude of genes implicated in kidney cancer, the Actin-Related Protein 2 (ACTR2) gene has lately received attention for its potential role in tumor development and disease furtherance. ACTR2 is an important member of the actin-related protein (ARP) group that participates in several cellular activities like cytoskeletal dynamics, intracellular transport, and gene expression control. The study aim to explore the functional implications of ACTR2 dysregulation in kidney cancer, highlighting its role in tumor cell proliferation, invasion, and resistance to conventional therapies. The study used quantitative Real-time polymerase chain reaction (qRT-PCR) to analyse gene expression rates in 11 cancer and 11 normal tissue samples from the kidney of the same patient. The research indicated a 1.206-fold elevation in ACTR2 gene expression in kidney cancer tissue samples relative to normal kidney tissues; however, this increase did not reach statistical significance (p = 0.234). Accordingly, we believe that further studies with large samples are needed to analyze and understand the ACTR2 expression level relationship to kidney cancer.