Evaluation of CO-peptin, NT-proBNP, pentraxin-3, LP-PLa2 serum levels in subjects with impaired fasting glucose and impaired glucose tolerance (prediabetic groups)

Co-peptin,NT- proBNP,pentraxin- 3 and Lp-PLA2 levels have been assessed in serum or plasma in subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and in healthy control to determine if any could be an early marker for prediabetes. Patients were recruited from the endocrinology outpatient department of Hafsa Sultan Hospital, Manisa. Fifty patients were enrolled in each group as IFG, IGT and healthy controls. Co-peptin, pentraxin-3 and Lp-PLA2 levels were determined in enous blood samples by an ELISA method. Plasma NT-proBNP measurement was done by an immunometric chemiluminescans method. For the statistical analyses, ANOVA variance, Banforoni and Pearson Correlation tests were used with SPSS 15.0 program. The groups were not statistically different in terms of gender, age, height and weight but waist circumferences were statistically different . Co-peptin, pentraxin-3 and NT-proBNP levels were significantly elevated in the prediabetic groups compared to the control group. The correlation analysis in the IGT group revealed that NT-proBNP,pentraxin-3 and co-peptin levels were all positively correlated. The results of our study support that an inflammatory process is involved and hyperglycemia underneath could have affected tissues and organs in the very early phases of prediabetes. Co-peptin, NT-proBNP and pentraxin-3 levels were significantly different in the prediabetic groups especially in IGT compared to the control group. Therefore, these markers could be potentially used as novel biomarkers in nondiabetic patients.for detecting IGT in the early stages.