Cinnamomum zeylanicum'un aterogeneze olan etkisi

Cinnamomum zeylanicum which is the true cinnamon belongs to Lauraceae family. Bark of the Cinnamon zeylanicum mainly consists of cinnamaldehyde which is the active compound. Active substances of Cinnamomum zeylanicum extract were found effective on reducing the blood glucose and lipid metabolism which are directly related to atherosclerosis and cardiovascular diseases. Atherosclerosis is a chronic inflammatory disease and primary cause of cardiovascular diseases. Our project seeks to assess the effect of Cinnamomum zeylanicum water extract on Nf-?B and sPLA2 in relation to atherogenesis in primary isolated rat aortic vascular smooth muscle (VSM) cells. In parallel to these studies animal experiments were performed to observe the effect of cinnamon on high cholesterol diet fed Wistar Hannover rats.The results of in vitro studies indicated that, 50µg/ml oxidized lipoprotein (ox-LDL) stimulates VSM cell proliferation in 24 hours and the co-treatment of 50µg/ml ox-LDL cinnamon extract containing 1µg/ml cinnamaldehyde and pure trans-cinnamaldehyde (1µg/ml) were not effective on the inhibition of VSM cell proliferation. Although ox-LDL had a proliferative effect on VSM cell, it diminished the active NF-?B levels. Moreover the treatment of cinnamaldehyde and cinnamon extract in the presence of ox-LDL (50µg/ml) led to a decrease in the active sPLA2 amount. Animals were fed with high cholesterol diet with or without of 300 mg/kg and 600 mg/kg cinnamon extract did not show a significant difference in the plasma cholesterol HDL, LDL, VLDL, triglyceride levels. Therefore, it is not possible to conclude whether cinnamon extract is efficient on reducing the progression of atherogenesis.