Effect of IV iron treatment on ECG parameters in patients with iron deficiency

Objective: The aim was to evaluate the effect of IV iron treatment on Electrocardiography (ECG) parameters in adult patients diagnosed with iron deficiency anemia (IDA) and indicated for intravenous (IV) iron treatment. Materials and Methods: Individuals aged 18 years and over who were diagnosed with IDA and indicated for IV iron therapy in the internal medicine and family medicine outpatient clinics of the Ordu University Education and Research Hospital of the Ministry of Health between November 5, 2023 and March 15, 2024 were included. Patients with heart failure, bundle branch block, atrial fibrillation, those receiving antiarrhythmic treatment, those receiving antimicrobial medication with active infection, those receiving psychiatric treatment, those who did not agree to participate in the study and those under the age of 18 were excluded from the study. The patients' age, gender, height, weight and CV, biochemistry, hemogram and ECG results were recorded. The ECGs and blood tests of the patients who were called for anemia check-up at the outpatient clinic one month later were recorded again. Results: P dispersion was found to be significantly lower in the IDA group than in the control group (p=0.003). R length (p=0.005) and R/S ratio (p=0.017) were found to be higher in the IDA group. No difference was found in the evaluation of R wave, S wave and R/S ratio before and after treatment. TP-e interval was found to be significantly lower in the IDA group (p<0.001). No significant difference was found between the TP-e before and after treatment. No significant difference was found between the groups in terms of QT (p=0.227) and QTc (p=0.151). QT/QTc interval was found to be higher in the IDA group (p=0.041). It was found that QT (p<0.001) and QT/QTc interval (p<0.001) increased significantly after IV iron treatment. Conclusion: It was found that there was no clinically significant difference in arrhythmic electrocardiographic parameters in patients with IDA before and after intravenous iron therapy. It was found that iron carboxymaltose therapy had no positive or negative effect on arrhythmic electrocardiographic markers in the early period in patients with IDA. Keywords: Iron deficiency anemia, iron carboxymaltose, electrocardiography