Investigation of the effect of exercise on meteorin-like and myonectin levels in an experimental hypertension model

The cause of hypertension is unknown in 95% of cases. Regular exercise has beneficial effects on hypertension. However, this mechanisms aren't understood. Myokines released during exercise may play an important role. It has been reported that Myonectin and Meteorin-like are released due to exercise. In our thesis, we aimed to investigate the role of Meteorin-like and Myonectin in the pathophysiology of hypertension, its relationship with kidney functions, and the effect of exercise on Meteorin-like and Myonectin levels. In our study, male Sprague Dawley rats were divided equally into 3 groups (n = 24; Control, Hypertension, Hipertension+Exercise). Rats in the Hypertension and Hipertension+Exercise were given L-NAME by adding it to their drinking water (6 weeks). Rats in the Hipertension+Exercise were subjected to running exercise on the treadmill 20 m/min, 45 minutes for the last 4 weeks. After collecting the 24-hour urine of the rats; Euthanasia was performed under anesthesia by removing blood, muscle and kidneys. It was determined that systolic, diastolic and mean arterial blood pressures increased and renal nitric oxide, muscle Myonectin and Meteorin-like concentrations decreased in the Hypertension compared to the C (p<0.05). It was observed that diastolic blood pressure, melondialdehyde and serum glucose levels decreased ( 4th-6th weeks) in the Hipertension+Exercise compared to the Hypertension (p<0.05). The decrease in this myokines muscle concentration indicates that they may have a role in the pathophysiology of hypertension. We think that the duration/type/starting time of exercise and dose of L-NAME should be reviewed. It should be investigated thoroughly for future research.