The effects of L-carnitinine supplementation on some muscle anabolic and catabolic signaling pathways in exercised rats

The effects of L-carnitine on some anabolic and catabolic signaling pathways in muscle were investigated. In this study, 6 groups (Control group, L-Carnitine, Exercise, Exercise + L-Carnitine, Acute Exercise and Acute Exercise + L-Carnitine) 7 including a total of 42 8-week-old male Wistar albino rats have been used. Rats were initially started to run 10 m / min. At the end of 2-weeks run period, 30 m / min, 0% grade, 30 minutes of jogging protocol has been applied with a controlled rise. After using L-Carnitine dietary, rats were subjected to a 5 days per week for 6 weeks of exercise and the last day of exercise protocol (rats running in the treadmill until exhaustion) was applied. Data were analyzed by using the PROC GLM procedure in the SAS packet program to reveal differences between the groups. Statistical significance was accepted as p<0.05. In conclusion, L-carnitine consumption in exercise applied rats had a positive effect by regulating muscle anabolic (mTOR and MyoD) and catabolic (FOXO1, MuRF1 and Myostatin) signaling pathways. It is thought that exercise performance and muscle development will improve in animals as a result of positive effects of these pathways. For this, more detailed studies are needed. Keywords: L-carnitine, Exercise, Muscle, Anabolic, Catabolic