IL-10 and IL-17 gene polymorphisms in adult idiopathic thrombocytopenic purpura

In adults ITP is primarily characterized by increased platelet destruction, it is chronic, acquired and organ specific autoimmune disorder. When the literature is analysed, many investigations about interleukin-10 and interleukin-17 gene polymorphisms in rheumatoid arthritis, Behçet?s disease, Graves' disease, ulcerative colitis, asthma, atopic dermatitis, celiac disease in which autoimmune disorder is associated with their pathogenesis are seen and there are significant differences in some of them. In ITP which is an immune-mediated disorder there are a few study. In this study we aim to investigate IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms and their serum levels in patients with ITP and control groups.After the investigation of IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms and their plasma levels in patients with ITP and control groups, no significant differences can be found in IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms and IL-17 serum levels between patients with ITP and control groups. However IL-10 serum levels are significantly higher in patients groups compared to control groups (p:0,003).We examined 50 patients with ITP and 51 healthy controls for gene polymorphisms and 32 patients with ITP and 32 healthy controls with ELISA for plasma levels. In addition we investigate the relationship between age, sex, treatment respond and platelet count in diagnosis in patients, IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms and their plasma levels in patients with ITP but there is no significant differences between groups.The result of this study ? there is no significant differences in IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms and IL-17 serum levels between patients with ITP and control groups- demonstrates that there may be no contribution of them in developing ITP. IL-10 serum levels are significantly higher in patients groups compared to control groups. There are lots of contradictory results in IL-10 serum levels in ITP patients. Large prospective studies of cytokine gene polymorphisms are needed to determine the role they play in ITP.