Eritrosit deformabilitesinde kayma gerilimi sonucu oluşan hasarın belirlenmesi

Mechanical damage or hemolysis in some cases, followed by exposure to high shear stress (≥100 Pa) was recorded in the previous studies. On the contrary, applying shear stress at physiological levels (5-20 Pa, 300 sec) was recently proved to improve erythrocyte deformability. This study aimed to analyze the erythrocyte deformability under shear stress exposure and to determine a breakpoint between improving and impairing erythrocyte deformability (i.e. Subhemolytic threshold). Our second goal was to examine the influence of frequency of intermittent shear stress exposure on subhemolytic threshold. Thirdly, two models of damage were involved in this study to observe how the subhemolytic threshold shifted when erythrocyte deformability was manipulated externally.