Synthesis of a new gadolinium containing polymer and investigation of spin-lattice relaxation time for its potential use as a contrast agent

In this thesis, a gadolinium based bio-compatible polymer has beensynthesized and its relaxivities has been calculated to search its potential useas a nuclear magnetic resonance imaging (MRI) contrast agent by usingFT-NMR spectrometer. Moreover, infrared spectra of the synthesizedpolymer is recorded with FT-IR spectrometer in the spectroscopic range ofthe (4000-400) cm-1 to search for possible coordination of Gd(III) ion. For thedetermination of Gd(III) ions concentration of the polymer in doteriumoxide (D2O) solution, ICP-OES (Inductively Coupled Plasma OpticalEmission Spectrometer) is employed. MALDI-TOF/MS (Matrix AssistedLaser Desorption Ionization Time of Flight Spectrometer) is used todetermine the molecular weight of the polymer structure. Toxicity of thepolymer is assessed in Swiss Albino male and female mice weighing (26-35)gusing Krebs-Henseleit as solvent for intraperitoneal injection. All relatedresults are also presented in this study.Keywords: Nuclear Magnetic Resonance, Relaxivity, Infrared Spectroscopy,Inductively Coupled Plasma Optical Emission Spectrometer,Toxicity