Investigation of genotype distribution and association with other sexually transmitted microorganisms in human papilloma virus positive patients

Cervical cancer is common in women all over the world and ranks second among cancers. The relationship between human papillomavirus and cervical cancer has been shown. More than 200 types of HPV have been identified to date and 40 of them are known to cause infection in the genital system. The aim of this study is to determine the genotypes in cervical specimens previously sent to the laboratory in which HPV was detected and to investigate whether other sexually transmitted agents are present in the same samples. In this study, high-risk HPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 67, 68) will be determined by real-time PCR test with target region E7 in archived cervical swab specimens of patients who applied to Balıkesir University Faculty of Medicine and Ege University Faculty of Medicine Hospital Gynecology and Obstetrics Outpatient Clinics between 2021 and 2024 were detected as HPV positive. In addition, the presence of twelve microorganisms that are STD agents (Candida albicans, Chlamydia trachomatis, Gardnerella vaginalis, Mycoplasma genitalium, Mycoplasma hominis, Neisseria gonorrhoeae, Ureaplasma parvum, Ureaplasma urealyticum, Treponema pallidum, Trichomonas vaginalis, Herpes simplex virus type 1 and 2) will be investigated in the same cervical specimens. In this context, how the simultaneous presence of HPV and STD pathogens is reflected in clinical results will be examined; thus, it will contribute to the development of more refined and effective strategies in diagnosis and treatment processes. It is aimed that this study will be an important step towards protecting and improving the health of individuals by adding an innovative dimension to the existing knowledge in the field of sexual health.