Discussion of tumoral process related markers Cytokeratin 5/6, Cytokeratin 14, HMWK, p27, CXCR-4 and SDF-1 in breast cancers

Breast cancer is the most common cancer and the most common reason in cancer death in women population. Early diagnosis and treatment are very important in breast cancers. The immunohistochemical markers which could have prognostic information are always needed.This study included 365 cases of invasive ductal carcinoma, ductal carcinoma in situ and ductal epithelial hyperplasia archived in Gazi University, Faculty of Medicine, Department of Pathology between 2006-2008. All histological slides were prepared with tissue microarray method and stained immunohistochemically to show expressions of HMWK, Cytokeratin 14, Cytokeratin 5/6, p27, CXCR-4 and SDF-1 markers with the information of lymph node status and tumor size.In conclusion, the higher CXCR-4 and SDF-1 expressions were associated with tumor progression, tumor size and lymph node status. Basal cytokeratins and p27 expressions were emphasized metastatic disease when they were used together. In benign proliferative lesions both HMWK and p27 expresions were helpful in differential diagnosis of borderline atypical ductal hyperplasia and ductal carcinoma in situ.