In obese women the relationship of PON1 activity with lipid metabolism.

Obesity is aserious disease with increasing importance all around the world; it increases the riskfor Type 2 Diabetes Mellitus, cardiovascular diseases and cancer. The aim of thisstudy was to identify the effects of serum lipids, Apolipoprotein A-I (Apo A-I),Apolipoprotein B (Apo B) and Paraoxanase 1 (PON1) activity on obesity in women.The study was conducted on 90 subjects categorized in three groups, there were 30women in each group with an age range of 18-48 years. Group I had 30 abdominalobese patients, Group II had 30 gynoid obeses and Group III included 30 healthycontrol subjects. For the patient and control groups, the following measurementswere performed: serum PON1 activity, total cholesterol, triglyceride (TG), HDLcholesterol (HDL-C), Apo A-I, Apo B, direct LDL cholesterol (D-LDL-C), highsensitive C-reactive protein (hsCRP), insulin and plasma glucose levels. There was astatistically significant difference between the triglyceride, HDL-C, Apo B, D-LDLC,hsCRP, HOMA-IR levels of Group I and II (p=0.001, p=0.000, p=0.016, p=0.001,p=0.000, p=0.000, respectively). For HDL-C, D-LDL-C, hsCRP, HOMA-IR levels,there were statistically significant differenced between Group I and III (p=0.023,p=0.023, p=0.000, p=0.001, respectively). There was significant positive correlationbetween total cholesterol and TG (p=0.000), Apo A-I (p=0.001), Apo B (p=0.000),D-LDL-C (p=0.000); between TG and Apo B (p=0.000), HOMA-IR (p=0.001), DLDL-C (p=0.000), BMI (p=0.001); between HDL-C and Apo A-I (p=0.000);between Apo B and D-LDL-C (p=0.000), BMI (p=0.007); between HOMA-IR andBMI (p=0.000); between D-LDL-C and BMI (p=0.000), hsCRP (p=0.013); finallybetween BMI and hsCRP (p=0.000). There was a significant negative correlationbetween triglyceride and HDL-C (p=0.007) and between HDL-C and BMI(p=0.000), hsCRP (p=0.025). TG, Apo B, HDL-C, D-LDL-C parameters differedsignificantly in abdominal obesity, whereas there was no difference among thegroups for PON1 activity. Having similar PON1 activity among the groups might berelated to several factors like genetic, demographic and metabolic.Key words: Arylesterase; Lipid Metabolizm; Obesity; Paraoxonase 1;Women.