Evaluation of the relationship between kidney volume measured by mr volumetry and platelet markers and glomerular filtration rate in patients with autosomal dominant polycystic kidney disease

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most important genetic causes of Chronic Kidney Disease (CKD), characterized by progressive cyst growth, which disrupts the structural integrity of the kidneys and leads to a decrease in glomerular filtration rate (GFR). Total kidney volume (TKV) measured by imaging techniques is used to evaluate disease progression. Platelet indices reflect not only hematological but also inflammatory and cardiovascular processes. The relationship between platelet markers-including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT)-and ADPKD remains unclear. This study aimed to investigate the relationship between TKV measured by MR volumetry and platelet markers as well as GFR in individuals with ADPKD. The study included a total of 100 patients diagnosed with ADPKD and 50 CKD patients with non-ADPKD etiology as controls. The ADPKD group was further divided into subgroups based on GFR values and the average TKV. No significant differences in platelet markers were found between ADPKD and control groups; however, ADPKD patients with GFR <60 mL/min had significantly lower PLT (p = 0.04) and PCT (p = 0.046). ADPKD patients showed a weak but significant negative correlation between TKV and PLT (r = -0.247, p = 0.013), and a significant negative correlation between TKV and PCT (r = -0.320, p = 0.001). Among patients with GFR ≥60 mL/min, a negative correlation was observed between TKV and PCT (r = -0.243, p = 0.032); and in those with GFR <60 mL/min, a significant negative correlation was found between TKV and platelet count (r = -0.480, p = 0.024). In patients with TKV above the average (1174.5 mL), significant negative correlations were found between TKV and PLT (r = -0.408, p = 0.003) and TKV and PCT (r = -0.306, p = 0.01). These findings suggest platelet indices may be influenced by increased TKV and decreased GFR in ADPKD, contributing to understanding their role in disease course and prognosis, and providing a basis for future large-scale studies.